Following a US court order, Pfizer has released a detailed list of side effects from its COVID-19 vaccines. The disclosure follows years of controversy and safety concerns surrounding these products, whose development was accelerated during the pandemic. The leaked document is nearly 300 pages long and lists the serious and moderate side effects associated with the vaccine.
Late threat detection
Like all COVID-19 vaccines, those developed for COVID-19 have side effects. However, their rapid development during this health crisis has raised legitimate concerns about their safety. For a long time, health authorities in many countries, including France, downplayed the occurrence of these side effects, likely to avoid slowing down mass vaccination campaigns under intense public pressure.
The currently available list illustrates the extent of this phenomenon. A further factor complicates the situation: not all vaccine batches are of the same quality, meaning that, depending on the batch, not all vaccinated individuals were exposed to the same risk.
Biological mechanism of turbocancer
Scientists had already raised the alarm during the first vaccination campaigns of 2021. Among them, Jean-Marc Sabatier, a PhD in cell biology and microbiology and head of research at the CNRS, documented a possible link between mRNA vaccines and the development of rapidly progressing tumors, so-called turbocancers.
According to his explanation, this phenomenon results from excessive activation of the AT1R receptor in the renin-angiotensin system. This system plays a key role in cell differentiation and proliferation. The spike protein produced after vaccination binds to the ACE2 receptor, thereby interrupting the degradation of angiotensin II. In excess, this causes overstimulation of the AT1R receptor, which has pro-tumor, pro-angiogenic, and pro-inflammatory properties.
The AT1R receptor also promotes oxidative stress, releasing cell-damaging free radicals. Antagonists of this receptor have been shown to have antitumor effects in various cancers, including breast, prostate, and lung cancer. Jean-Marc Sabatier described in March 2020, long before the first cases were reported, a carcinogenic effect resulting from disruption of this system by the SARS-CoV-2 spike protein.
